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PubMed · 7018725

2'-deoxycoformycin. A new anticancer agent.

D S Poster·J S Penta·S Bruno·J S Macdonald
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Abstract

2'-deoxycoformycin (2'-dCF) is a powerful inhibitor of adenosine deaminase (ADA), an enzyme found in high concentrations in lymphoid tissue. Although inactive in preclinical tumor models, 2'-dCF has shown clinical antitumor activity as a single agent in lymphoid malignancies. This drug has the added potential of being useful as a potentiator of other antitumor agents which are deactivated by ADA. It is also possible that the drug has potential as an immunosuppressive agent. Phase I studies are ongoing and phase II trials are planned to define the antitumor spectrum of this agent.

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AnimalsAntineoplastic AgentsCoformycinHumansKineticsNeoplasms, ExperimentalPentostatinRibonucleosidesJournal ArticleReview

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D S Poster, J S Penta, S Bruno, J S Macdonald. 1981. 2'-deoxycoformycin. A new anticancer agent.. https://pubmed.ncbi.nlm.nih.gov/7018725/

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