Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture.

C R Brockelman; S Monkolkeha; P Tanariya

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PubMed · 7018728

Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture.

C R Brockelman·S Monkolkeha·P Tanariya

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Abstract

Chloroquine-resistant P. falciparum, line FCK from Thailand, was tested for susceptibility to mefloquine in continuous culture. The drug resulted in 50% schizont inhibition at the level of 8.0 nmol/ml of culture when tested for the first time. After three months of discontinuous exposure to mefloquine at increasing levels, the sensitivity of the parasite decreased. A concentration as high as 128 nmol/ml eventually was required for 50% inhibition of growth.

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Animals Chloroquine Culture Media Drug Resistance, Microbial Humans In Vitro Techniques Malaria Mefloquine Piperidines Plasmodium falciparum Quinolines Journal Article Research Support, Non-U.S. Gov't

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C R Brockelman, S Monkolkeha, P Tanariya. 1981. Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture.. https://pubmed.ncbi.nlm.nih.gov/7018728/

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