The evolving tRNA molecule.

R J Cedergren; D Sankoff; B LaRue; H Grosjean

doi:10.3109/10409238109108699

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The evolving tRNA molecule.

R J Cedergren·D Sankoff·B LaRue·H Grosjean

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Abstract

The study of tRNA molecular evolution is crucial to understanding the origin and establishment of the genetic code as well as the differentiation and refinement of the machinery of protein synthesis in prokaryotes, eukaryotes, organelles, and phage systems. The small size of the molecule and its critical involvement in a multiplicity of roles distinguish its study from classical protein molecular evolution with respect to goals and methods. Here, the authors assess available and missing data, existing and needed methodology, and the impact of tRNA studies on current theories both of genetic code evolution and of the evolution of species. They analyze mutational "hot spots", the role of base modification, synthetase recognition, codon-anticodon interactions and the status of organelle tRNA.

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Animals Anticodon Base Sequence Biological Evolution Codon DNA Replication Genes Genetic Code Models, Genetic Molecular Conformation Mutation Nucleic Acid Conformation Phylogeny RNA, Transfer Journal Article Research Support, Non-U.S. Gov't Review

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R J Cedergren, D Sankoff, B LaRue, H Grosjean. 1981. The evolving tRNA molecule.. https://doi.org/10.3109/10409238109108699

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