Structure-function relationships in hemoglobins: scientific aspects.

K Moffat

PubMed · 7034268

Structure-function relationships in hemoglobins: scientific aspects.

Abstract

Both proximal and distal molecular processes which could contribute to lowered ligand affinity, and hence to cooperativity, have been identified from a comparison of macromolecular structures; most have been successfully modelled by ingenious model heme derivatives. More work is needed to decide which of these processes are operative at each stage of the ligand binding process, which is both kinetically and structurally complex.

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Binding Sites Chemical Phenomena Chemistry Crystallography Heme Hemoglobins Humans Kinetics Ligands Macromolecular Substances Protein Conformation Journal Article Research Support, U.S. Gov't, P.H.S.Review

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K Moffat. Structure-function relationships in hemoglobins: scientific aspects.. https://pubmed.ncbi.nlm.nih.gov/7034268/

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