Responsiveness to HY antigen Ir gene complementation and target cell specificity.

E Simpson; R D Gordon

doi:10.1111/j.1600-065x.1977.tb00235.x

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Responsiveness to HY antigen Ir gene complementation and target cell specificity.

E Simpson·R D Gordon

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Abstract

The H-2 restricted nature of the cytotoxic T cell responses to the HY antigen in mice has been reviewed, together with mapping data for the H-2 K and/or D association of responses to male cells of the following haplotypes: H-2b, H-2d, H-2k, H-2s. Ir gene complementation is implicated in the HY response of a number of F1 mice derived from non-responder parental haplotypes, and in one recombinant strain. Thus, at least two and possibly more Ir genes are involved in the anti-HY response, in addition to the K and/or D gene products with which HY is obligatorily associated, certainly at the target cell level.

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Animals Antigen-Antibody Reactions Chromosome Mapping Cytotoxicity Tests, Immunologic Epitopes Female Genetic Complementation Test Haploidy Histocompatibility Antigens Immunity, Cellular Lymphocyte Activation Male Mice Mice, Inbred Strains Spleen T-Lymphocytes Journal Article Review

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E Simpson, R D Gordon. 1977. Responsiveness to HY antigen Ir gene complementation and target cell specificity.. https://doi.org/10.1111/j.1600-065x.1977.tb00235.x

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