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PubMed · 7040848

Hypolipidemia.

M J Malloy·J P Kane
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Abstract

Clinically significant hypolipidemia, although less common than hyperlipidemia, usually has important consequences that involve derangement of one or more of the major roles of lipoproteins. Deficiencies of lipoproteins are discussed under their classification as genetic disorders or as the presenting features of underlying disease.

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AbetalipoproteinemiaChylomicronsHumansHypobetalipoproteinemiasHypolipoproteinemiasImmunoglobulinsLecithin Cholesterol Acyltransferase DeficiencyLipoproteinsLiver DiseasesNutrition DisordersTangier DiseaseTriglyceridesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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BibTeXRIS

M J Malloy, J P Kane. 1982. Hypolipidemia.. https://doi.org/10.1016/s0025-7125(16)31431-6

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Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia.

Abetalipoproteinemia is a human genetic disease that is characterized by a defect in the assembly or secretion of plasma very low density lipoproteins and chylomicrons. The microsomal triglyceride transfer protein (MTP), which is located in the lumen of microsomes isolated from the liver and intestine, has been proposed to function in lipoprotein assembly. MTP activity and the 88-kilodalton component of MTP were present in intestinal biopsy samples from eight control individuals but were absent in four abetalipoproteinemic subjects. This finding suggests that a defect in MTP is the basis for abetalipoproteinemia and that MTP is indeed required for lipoprotein assembly.

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