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PubMed · 7042607

Primary dapsone-resistant leprosy in Cebu, Philippines.

R S Guinto·R V Cellona·T T Fajardo·E C de la Cruz
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Abstract

A survey of the prevalence of primary dapsone-resistant leprosy in Cebu, Philippines, has yielded an estimate of 3.6 per 100. Fifty-three of 55 patients proved to have M. leprae fully susceptible to dapsone. The organisms of two patients multiplied in mice administered the minimal effective dose of dapsone; and those of one of these patients also multiplied in mice administered dapsone in a 10-fold larger dose.

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AnimalsDapsoneDrug Resistance, MicrobialHumansLeprosyMiceMice, Inbred CBAMycobacterium lepraePhilippinesJournal ArticleResearch Support, Non-U.S. Gov't

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R S Guinto, R V Cellona, T T Fajardo, E C de la Cruz. 1981. Primary dapsone-resistant leprosy in Cebu, Philippines.. https://pubmed.ncbi.nlm.nih.gov/7042607/

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