Analytical methods for microbiology in the next decade.

Abstract

As microbiologists develop and modify methods and turn to automated equipment to decrease analysis time, the precision and accuracy of the methods must be ensured through collaborative study. Rapid, validated methods are needed in many areas. Sterility testing and the use of biological indicators are among subjects of interest to FDA and industry. These groups are also studying particulate analysis. The limulus amebocyte lysate test is being considered for use in detecting endotoxins in drugs and medical devices, in diagnosing illness, and in assessing the microbiological quality of foods and water. Reliable methods are needed for detecting viruses in foods to assure a safe food supply. Studies are needed on the Vibrionaceae to better understand the mechanisms of invasiveness and host response. Methods must also be developed to study pathogens in the water and food supply.