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PubMed · 7047833

Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection.

D Cupissol·A Rey·A L Goldstein·B Serrou
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Abstract

The effect of iv injection in C57BL/6 mice of 3X10(7) bone marrow cells preincubated in either thymosin fraction V or thymosin alpha-1 was evaluated on the growth of a 3-methylcholanthrene-induced transplantable tumor in a syngeneic system. The effect was then compared to that elicited by theophylline or levamisole, which both demonstrated thymosin-like action in vitro. The results showed significantly retarded tumor growth (P less than 0.001) and prolonged survival time (P less than 0.001) when thymosin fraction V was used. The same results were obtained with thymosin alpha-1 with use of the same protocol but only one-twentieth of the concentration of fraction V. Theophylline and levamisole demonstrated no antitumor effect.

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AnimalsBone Marrow TransplantationCell DivisionLevamisoleMaleMethylcholanthreneMiceMice, Inbred C57BLNeoplasm TransplantationNeoplasmsTheophyllineThymosinThymus HormonesTime FactorsJournal ArticleResearch Support, Non-U.S. Gov't

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D Cupissol, A Rey, A L Goldstein, B Serrou. 1982. Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection.. https://pubmed.ncbi.nlm.nih.gov/7047833/

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