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PubMed · 7050038

Radiosensitization by non-nitro compounds.

P Wardman·R F Anderson·R J Hodgkiss·J Parrick·C E Smithen·R G Wallace·M E Watts
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Abstract

The effects of 23 non-nitro compounds on the radiosensitivity of hypoxic Chinese hamster V79-379A or E. coli AB 1157 cells in vitro are outlined. Imidazole derivatives substituted with several alternative electron-withdrawing groups are described; the dicyanovinyl function conferred considerable radiosensitizing activity. 2,4,5-Tribromoimidazole and 2,4-dinitrophenol may show unusual radiosensitizing activity because of interference with oxidative phosphorylation. Attempts to influence radiosensitivity by compounds potentially capable of depleting intracellular sulphydryls are also described.

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AnimalsCell LineCricetinaeCricetulusElectronsEscherichia coliRadiation-Sensitizing AgentsSulfhydryl CompoundsUncoupling AgentsJournal ArticleResearch Support, Non-U.S. Gov't

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P Wardman, R F Anderson, R J Hodgkiss, J Parrick, C E Smithen, R G Wallace, M E Watts. Radiosensitization by non-nitro compounds.. https://doi.org/10.1016/0360-3016(82)90647-2

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