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Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors.

I N Mefford·K A Roth·J D Barchas
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Abstract

The effect of acute phenylethanolamine-N-methyltransferase (PNMT) inhibition on rat brain catecholamine concentrations was studied. All PNMT inhibitors tested were effective in depleting hypothalamic and brain stem epinephrine. Norepinephrine concentrations were unaffected; however, dopamine levels were increased in all areas studied. While several possible explanations are offered for this phenomenon, the mechanism is not yet understood.

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AnimalsBrain StemCatecholaminesChromatography, High Pressure LiquidHypothalamusMalePhenylethanolamine N-MethyltransferaseRatsRats, Inbred StrainsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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I N Mefford, K A Roth, J D Barchas. 1980-10-20. Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors.. https://doi.org/10.1016/0304-3940(80)90235-9

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