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PubMed · 7055847

Surface activity and human blood platelet aggregation-inhibitory potency.

R P Quintana·A Lasslo·G S Queen
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Abstract

Surface and interfacial activity is correlated with molecular constitution and inhibitory potency of mono- and bis(carbamoylpiperidino)alkanes and aralkanes, and of some corresponding quaternary pyridinium congeners, in ADP-induced human blood platelet aggregation. The measurements of surface and interfacial tension were carried out at concentrations and pH-values approximating those employed in the hemodynamic study. The effect of changes in chemical structure, ranging from relatively minor variations in a specific functional group to the alteration of major components in molecular constitution, was examined and interpreted in terms of contemporary theoretical chemistry.

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HumansModels, MolecularPiperidinesPlatelet AggregationStructure-Activity RelationshipSurface PropertiesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R P Quintana, A Lasslo, G S Queen. 1982. Surface activity and human blood platelet aggregation-inhibitory potency.. https://doi.org/10.1016/0009-2797(82)90035-7

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