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PubMed · 7056640

Ca++-induced cataract.

K R Hightower·V N Reddy
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Abstract

Cataracts in cultured rabbit lenses were produced by elevation of internal calcium. Experimental procedures were successful in increasing levels of total and bound Ca++, often without significant changes in sodium, potassium, or water content. Although the excess in calcium was predominantly associated with water-soluble proteins and was freely diffusible, a significant amount was bound to membranes and cytosol water-insoluble proteins. Thus, in lenses with a 10-fold increase in total Ca++, the bound Ca++ increased twofold, nearly 35% of which remained fixed to water-insoluble and membrane proteins after exhaustive (72 hr) dialysis. In contrast, over 95% of the Ca++ in water-soluble protein fractions was removed by dialysis.

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AnimalsCalciumCataractCrystallinsLens, CrystallineRabbitsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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K R Hightower, V N Reddy. 1982. Ca++-induced cataract.. https://pubmed.ncbi.nlm.nih.gov/7056640/

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