Sympathetic immunoregulation: difference between high- and low-responder animals.

A del Rey; H O Besedovsky; E Sorkin; M Da Prada; G P Bondiolotti

doi:10.1152/ajpregu.1982.242.1.r30

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Sympathetic immunoregulation: difference between high- and low-responder animals.

A del Rey·H O Besedovsky·E Sorkin·M Da Prada·G P Bondiolotti

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Abstract

A quantitative relationship is reported between the magnitude of the immune response of rats to sheep red blood cells and diminution of splenic norepinephrine (NE). A decrease in concentration and content of NE in the spleen on day 3 after immunization was evident in both high- and low-responder animals, whereas a diminished concentration of NE persisted only in the high responders. This continuing NE diminution in high-responder animals is associated with increase in spleen weight, probably attributable to blood accumulation. These findings are consonant with the concept that the sympathetic nervous system is involved in immunoregulation.

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Animals Antibody Formation Erythrocytes Female Norepinephrine Organ Size Rats Sheep Spleen Sympathetic Nervous System Journal Article Research Support, Non-U.S. Gov't

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A del Rey, H O Besedovsky, E Sorkin, M Da Prada, G P Bondiolotti. 1982. Sympathetic immunoregulation: difference between high- and low-responder animals.. https://doi.org/10.1152/ajpregu.1982.242.1.r30

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