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PubMed · 7059465

Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.

C Burtin·P Scheinmann·J C Salomon·G Lespinats·P Canu
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Abstract

C3H and C57 BL/6 mice carrying methylcholanthrene-induced fibrosarcomas were injected i.p. daily with histamine, metiamide (anti-histamine type-2 receptor), histamine + metiamide, mepyramine (anti-histamine type-1 receptor), serotonin and methysergide (anti-serotonin). Inhibition of tumour growth and lengthened survival were observed with histamine and histamine + metiamide. The best results (both on tumour growth and survival) were obtained with serotonin. Survival was increased by metiamide and decreased by mepyramine and methysergide. In histamine-treated and in serotonin-treated mice, histological studies of the tumours showed large and numerous foci of haemorrhagic necrosis. Stimulation of histamine type-1 or serotonin receptors and inhibition of histamine type-2 receptors play a beneficial role in the host's defence against tumours.

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AnimalsFibrosarcomaHistamineMaleMethysergideMetiamideMiceMice, Inbred C3HMice, Inbred C57BLPyrilamineReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H2Sarcoma, ExperimentalSerotoninJournal Article

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C Burtin, P Scheinmann, J C Salomon, G Lespinats, P Canu. 1982. Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors.. https://doi.org/10.1038/bjc.1982.7

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