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PubMed · 7067226

Bone aging.

G T Syftestad·M R Urist
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Abstract

Bone matrix of 28-month-old (senescent) rats, compared with 13-month-old rats, is strikingly deficient in the capacity to induce bone formation. Similarly, implants of senescent matrix into one-month-old, rapidly-growing rats (weanlings) produce more bone than in 13-month-old adult recipients, but not nearly enough to compensate for deficiency in the matrix of senile bone. Matrix prepared from the bone of 13-month-old rats also produces almost no cartilage and significantly lower yields of new bone in 28-month-old (senescent) than 13-month-old rats. These observations suggest that progressive decline in the matrix morphogenetic activity of bone occurs with time in adult life. This decline is a tissue specific index of bone aging, and may contribute to the reduction of bone mass that normally occurs with senescence.

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Age FactorsAgingAnimalsBone MatrixBone and BonesCalciumCartilageHumansMaleOsteogenesisRabbitsRatsRats, Inbred F344Tissue DonorsUronic AcidsJournal ArticleResearch Support, Non-U.S. Gov't

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G T Syftestad, M R Urist. Bone aging.. https://pubmed.ncbi.nlm.nih.gov/7067226/

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