PubMed Health⌕ Search

PubMed · 7069986

[Indications for coronary arteriography].

Abstract

Visualization of the lumen of the coronary arteries by angiography has greatly expanded the ability of the physician to evaluate the extent of disease in patients suspected of having an ischaemic cardiac disorder. Criteria for coronary angiography have been developed in part by reviewing the experience in the Coronary Artery Surgery Study, CASS. During a five year period at 15 participating sites 24959 consecutive patients undergoing angiography for suspicion of coronary artery disease were enrolled. Chest pain was the dominant symptom in more than 80%. Unstable angina occurred in more than 1/3 of patients classified as definite or probably angina pectoris. The majority of patients were in Canadian Class 2,3. In a study previous reported by CASS a mortality of 002 and a morbidity (myocardial infarction) of 003 was found; presence of left main disease increased mortality 6.8 times. In males, 79% had significant and 12% no CAD; left main disease occurred in 9%. In females 45% had significant and 40% no CAD; left main disease occurred in 4%. The distribution of 1,2 and 3 vessel disease will be presented. From these data and a survey of clinical experience during the past several years, 10 indications for visualization of the coronary artery anatomy by angiography have been developed. These indications are presented for discussion.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

T h Killip. 1982. [Indications for coronary arteriography].. https://pubmed.ncbi.nlm.nih.gov/7069986/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

Angina Pectoris↗