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PubMed · 7073232

Therapeutic problems relating to azotaemic osteodystrophy.

Y L Chan·S Posen
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Abstract

Azotaemic osteodystrophy is a generic term encompassing the different bony lesions found in renal failure. The most important of these are parathyroid osteopathy and osteomalacia which may co-exist or occur singly. Both types of lesions have multifactorial aetiologies. Hyperparathyroidism is caused by hyperphosphataemia, hypocalcaemia and possibly, a lack of 1,25-dihydroxycholecalciferol. Osteomalacia is caused by vitamin D deficiency, a lack of dihydroxylated vitamin D metabolites and aluminium intoxication. Treatment modalities include phosphate binders, a tight control of calcium concentrations in the dialysis fluid, vitamin D and parathyroidectomy. Each of these is associated with certain hazards. In particular, vitamin D and parathyroidectomy may cause deterioration of residual renal function.

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CalciumChronic Kidney Disease-Mineral and Bone DisorderHumansHyperparathyroidismKidney Failure, ChronicOsteomalaciaUremiaVitamin D DeficiencyJournal ArticleResearch Support, Non-U.S. Gov't

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Y L Chan, S Posen. 1982. Therapeutic problems relating to azotaemic osteodystrophy.. https://pubmed.ncbi.nlm.nih.gov/7073232/

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