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PubMed · 7091899

Experimental diffuse alveolar damage in baboons.

W G Johanson·J R Holcomb·J J Coalson
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Abstract

Lung repair after diffuse alveolar damage (DAD) may be modified by supportive therapy or the occurrence of complications. To provide a clinically relevant model of DAD, we studied the feasibility of long-term respiratory support of 5 normal baboons and 20 baboons with oleic-acid-induced lung injury. Oleic acid caused DAD, which evolved through exudative and reparative phases similar to those seen in human disease. Fibrotic residuals were present at 1 month but resolved by 6 months. Pulmonary function abnormalities, including reduction in total lung capacity and diffusing capacity, and hypoxemia occurred with DAD but resolved within 1 month. Bronchopulmonary infection with gram-negative bacilli was a common and frequently fatal complication. Revisions in management of the upper airway and the use of topical polymyxin B prevented this complication. Other complications included hemorrhagic gastritis, postextubation, upper airway obstruction, and pulmonary embolism. This model simulates many features of DAD in humans and should provide a valuable resource for future study.

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Acute DiseaseAnimalsCarbon MonoxideDisease Models, AnimalMaleOleic AcidOleic AcidsOxygenPapioPulmonary AlveoliRespiratory InsufficiencyTotal Lung CapacityJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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W G Johanson, J R Holcomb, J J Coalson. 1982. Experimental diffuse alveolar damage in baboons.. https://doi.org/10.1164/arrd.1982.126.1.142

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