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PubMed · 7097778

Oligonucleotide formation catalyzed by mononucleotide matrices.

R Lohrmann
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Abstract

Pb2+-containing precipitates of mononucleotides form matrices which catalyze the self-condensation of nucleotide 5'-phosphorimidazolides and their condensation with nucleosides. The reactions exhibit base-pairing specificity between matrix nucleotide and substrate, and usually follow the Watson-Crick pairing rules. Although purine polynucleotides do not facilitate the oligomerization of pyrimidine nucleotide monomers in solution, it is interesting that purine-containing matrices do catalyze such a reaction. The significance of the results in the context of the prebiotic evolution of polynucleotides is discussed.

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Adenine NucleotidesChemical PhenomenaChemistryChromatography, PaperLeadNucleotidesOligonucleotidesOligoribonucleotidesJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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R Lohrmann. 1982. Oligonucleotide formation catalyzed by mononucleotide matrices.. https://doi.org/10.1007/bf01733045

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