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Monocyte interactions with solid substrates monitored by chemiluminescence.

P J Parks·B P Barna·M G Edinger·S D Deodhar
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Abstract

The kinetics of interaction of solid substrates with mononuclear cells is a little explored by important feature in the evaluation of potential prosthetic materials. Monocyte production of chemiluminescence in a luminol-enhanced system was used to explore such kinetics. A theoretical model of cell/surface interaction is developed and alternatives in the evaluation of data generated by chemiluminescent curves are presented. The interactions of monocytes with a polytetrafluoroethylene (PTFE) surface were similar to those seen in studies on phagocytosis and were dependent on an absorbed serum protein layer. This study illustrates the use of a simple laboratory test for monocyte oxidative function in assessing the potential inflammatory effects of various prosthetic materials.

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Biocompatible MaterialsEvaluation Studies as TopicHumansInflammationLuminescent MeasurementsMonocytesOpsonin ProteinsPhagocytosisPolytetrafluoroethyleneTime FactorsJournal Article

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P J Parks, B P Barna, M G Edinger, S D Deodhar. 1982. Monocyte interactions with solid substrates monitored by chemiluminescence.. https://doi.org/10.3109/10731198209118770

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