Age-related decrease in the activity of UDP-xylose:core protein xylosyltransferase in rat costal cartilage.

B Wolf; A M Gressner; Z Nevo; H Greiling

doi:10.1016/0047-6374(82)90009-4

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Age-related decrease in the activity of UDP-xylose:core protein xylosyltransferase in rat costal cartilage.

B Wolf·A M Gressner·Z Nevo·H Greiling

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Abstract

The activity of UDP-xylose:core protein xylosyltransferase (EC 2.4.2.26) in costal cartilage of young rats (3 months) and old rats (36 months) was measured. The enzyme activity in cartilage of young rats (mean +/- S.D.) is 3370 +/- 1440 Bq h-1 mg-1 DNA, which is about three times higher than that determined in cartilage of old rats (1090 +/- 520 Bq h-1 mg-1 protein). The amount of galactosamine-containing proteoglycosaminoglycans that are extractable with 4 M guanidinium chloride from cartilage is significantly higher in young rats (29.1 +/- 4.8 nmol GalN per mg cartilage wet weight) than in old animals (5.8 +/- 3.0 nmol GalN per mg cartilage wet weight). Thus, if xylosyltransferase activity is referred to the amount of galactosamine-containing proteoglycans in cartilage, nearly identical values are obtained (young rats, 80 +/- 30 Bq h-1 mumol-1 GalN; old rats, 85 +/- 35 Bq h-1 mumol-1 GalN). The results support the assumption that the synthesis of proteochondroitin sulfate is diminished in costal cartilage of old rats by a mechanism involving a reduced activity of xylosyltransferase.

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Aging Animals Cartilage Hexosamines L-Lactate Dehydrogenase Male Pentosyltransferases Proteoglycans Rats Rats, Inbred Strains UDP Xylose-Protein Xylosyltransferase Journal Article Research Support, Non-U.S. Gov't

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B Wolf, A M Gressner, Z Nevo, H Greiling. 1982. Age-related decrease in the activity of UDP-xylose:core protein xylosyltransferase in rat costal cartilage.. https://doi.org/10.1016/0047-6374(82)90009-4

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