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[Benzenedithiol esters with antimycotic activity].

F Pavanetto·L Montanari·T Modena·M Mazza
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Abstract

Some diesters of benzen-1,2-dithiol wit aliphatic and aromatic carboxylic acids were prepared and tested for in vitro antifungal activity. The diacetate and dipropionate of benzen-1,3- and 1,4-dithiol were used as comparison compounds. The substances (Table I; substances I leads to X) were obtained by condensation of benzenedithiols with suitable acylating agents. The fungistatic activity of the products was tested in vitro against the following fungal strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diester of benzen-1,2-dithiols with alkanoic acids (Table I) have marked antimycotic activity, much greater than that of clotrimazol. The diaroyl esters of benzen-1,2-dithiol and the diesters of benzen-1,3- and 1,4-dithiols are inactive or only slightly active.

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Antifungal AgentsBenzene DerivativesChemical PhenomenaChemistrySulfhydryl CompoundsEnglish AbstractJournal Article

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F Pavanetto, L Montanari, T Modena, M Mazza. 1982. [Benzenedithiol esters with antimycotic activity].. https://doi.org/10.1002/chin.198245178

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