Behavioural data on dermorphins in mice.

S Puglisi-Allegra; C Castellano; U Filibeck; A Oliverio; P Melchiorri

doi:10.1016/0014-2999(82)90518-0

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Behavioural data on dermorphins in mice.

S Puglisi-Allegra·C Castellano·U Filibeck·A Oliverio·P Melchiorri

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Abstract

Dermorphin, an opioid peptide occurring in amphibian skin, exerted a depressive effect on locomotor activity of C57B1/6 mice and an analgesic effect when injected intravenously. Intracerebroventricular injections of dermorphin enhanced locomotor activity and resulted in analgesia. A stimulating effect of intracerebroventricular administration on locomotor activity was also induced by shorter homologues of dermorphin and [D-Ala2, Leu5]enkephalinamide, while beta-endorphin produced a depression. It is suggested that dermorphin acts on central receptor populations activated by morphine and enkephalins.

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Animals Behavior, Animal Enkephalin, Leucine Enkephalin, Leucine-2-Alanine Injections, Intravenous Injections, Intraventricular Male Mice Mice, Inbred C57BL Motor Activity Oligopeptides Opioid Peptides Reaction Time Journal Article Research Support, Non-U.S. Gov't

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S Puglisi-Allegra, C Castellano, U Filibeck, A Oliverio, P Melchiorri. 1982-08-27. Behavioural data on dermorphins in mice.. https://doi.org/10.1016/0014-2999(82)90518-0

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