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PubMed · 7135157

Hyperbaric ethanol antagonism in mice: time course.

R L Alkana·R D Malcolm
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Abstract

C57BL/6J mice were injected intraperitoneally with 3.6 g/kg ethanol and exposed to 1 ATA air or to 1 or 12 ATA helium-oxygen immediately, 5, 10 or 20 minutes after injection. Immediate and delayed hyperbaric exposure produced similar significant reductions in sleep-times and increases in wake-up brain ethanol concentrations. These findings demonstrate the effectiveness of delayed hyperbaric treatment in reducing ethanol sleep-time and eliminate decreased absorption and altered distribution as critical factors mediating the antagonism. The results are consistent with current theories of anesthesia and support a direct mechanism involving brain cellular membranes.

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AnimalsBrainCell MembraneEthanolHeliumHyperbaric OxygenationMaleMiceMice, Inbred C57BLOxygenSleepTime FactorsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R L Alkana, R D Malcolm. 1982. Hyperbaric ethanol antagonism in mice: time course.. https://pubmed.ncbi.nlm.nih.gov/7135157/

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