PubMed · 7140161
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S Hansen, D L Sutton. 1982. Electroencephalograph programme tester.. https://doi.org/10.1088/0143-0815%2F3%2F3%2F007
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Fractal dimensions has been proposed as a useful measure for the characterisation of electrophysiological time series. But one of the problems of this approach, is the difficulty to record time series long enough of determine the 'real' fractal dimension. Nevertheless it is possible to calculate fractal dimensions for very short data-segments. Using time series of different length it is possible to show, that there is a monotoneous relation between fractal dimension and the number of data-points. This relation could be further interpreted with the help of an extrapolation scheme. In addition this effect is also seen with surrogate data, generated from that signal. We conclude that it is feasible to use fractal dimension as a tool to characterise the complexity for short electroencephalographic (EEG) time series, but it is not possible to decide whether the brain is a chaotic system or not.
The newborn brain is particularly vulnerable to seizures which are associated with poor neurodevelopmental outcome. The clinical manifestations of seizures in infants differ from those seen in older children and adults. The problem of electro-clinical dissociation, where there is no temporal correspondence between electrical paroxysms and repetitive stereotyped motor phenomena, is common in the newborn. There is at present very little information on which clinicians can base a rational decision about treatment which is often ineffective and does not alter neurodevelopmental outcome. This review summarizes current knowledge regarding investigation, treatment and prognosis of neonatal seizures.
Interictal spikes on intraoperative electrocorticography during epilepsy are used to tailor resections. There have been a few systematic quantitative studies of anesthetic effects on these interictal discharges, and none on the effects of nitrous oxide (N2O). We calculated spike rates on ECoG on and off N2O in 18 epilepsy surgery patients with subdural strips and grids, analyzing the most active recording contract. In a blinded analyses ten patients had fewer spikes on N2O, while eight patients had more spikes on N2O. The mean spike rates did not differ (41/min on N2O and 40/min off N2O). Spike rate on and off N2O were compared using the non-parametric Wilcoxon matched pairs test. These rates were not significantly different. Our study indicates that N2O in doses employed dose not effect interictal spikes and this agent may be used during epilepsy surgery without concerns about suppression of epileptiform activity.