PubMed Health⌕ Search

PubMed · 714369

Optic nerve changes in chorioidal malignant melanoma.

Abstract

The optic nerve has been investigated in 11 cases of chorioidal malignant melanoma. 10 cases showed central fascicular degeneration surrounded by a rim of myelinated nerve fibers. Microglia was regularly found demarkating the central changes and often within the demyelinated areas. The changes were found within all quadrants of the nerve and without any apparent correlation with defects in the visual field.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

P Naeser. 1978. Optic nerve changes in chorioidal malignant melanoma.. https://doi.org/10.1159/000308734

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Detection of BRAF gene mutation in primary choroidal melanoma tissue.

Numerous BRAF mutations have been detected in melanoma biopsy specimens and cell lines. In contrast, several studies report lack of BRAF mutations in uveal melanoma including primary and metastatic choroidal and ciliary body melanomas. To our knowledge, for the first time, here we report a case of choroidal melanoma harboring the BRAF mutation (V600E). The activation of RAF/MEK/ERK pathway, although independent of BRAF mutation, was reported in uveal melanoma. The presence of V600E mutation indicates that the RAF/MEK/ERK pathway, in addition to cutaneous melanoma progression, may play a role in the choroidal melanoma development.

Choroid Neoplasms↗