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PubMed · 71499

Is dextran 70 a lymphocyte mitogen?

A C Burden·R L Stacey·R Windle·R F Wood·P R Bell
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Abstract

Dextran 70 ('Lomodex') roduced significant increases in thymidine incorporation in a modified whole-blood method of investigating lymphocyte blastogenesis. This blastogenesis occurred at molar concentrations of 7 X 10(-6) and 7 10(-5). At 7 X 10(-7) mol/l dextran alone did not significantly increase thymidine incorporation; however, when this concentration of dextran was added simultaneously with phytohaemagglutinin there was a significant increase in incorporation. Conversely when dextran was added before P.H.A., thymidine incorporation was decreased. These variable effects indicate that dextran 70 may be a B-cell mitogen. Dextran 70 is widely used and these effects on lymphocyte blastogenesis may be clinically relevant.

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B-LymphocytesCell Transformation, NeoplasticCells, CulturedDextransHumansIn Vitro TechniquesLectinsMitogensStimulation, ChemicalThymidineTime FactorsComparative StudyJournal Article

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A C Burden, R L Stacey, R Windle, R F Wood, P R Bell. 1977-10-01. Is dextran 70 a lymphocyte mitogen?. https://doi.org/10.1016/s0140-6736(77)90498-6

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