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PubMed · 7154864

A demonstration that 5-hydroxytryptamine administered peripherally can affect sexual behavior in male rats.

G Gonzales·L Mendoza·J Ruiz·J Torrejón
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Abstract

In the male rat, subcutaneous injections for 7 days of 20 mg/Kg B.W./day of 5-hydroxytryptamine creatinin sulphate (5-HT), caused remarkable inhibitory effects on sexual behavior. The mount and intromission latencies were increased in rats treated with 5-HT, whereas ejaculation latency in the few rats treated with 5-HT that it achieved, was similar to that obtained in control rats. The mount and intromission frequencies were decreased in the rats treated with 5-HT. The mean inter-intromission interval (MIII) and post-ejaculatory interval were prolonged in rats treated with 5-HT. These data provide evidence for the role of peripheral 5-HT in regulating sexual behavior of male rats.

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AnimalsBlood-Brain BarrierCopulationCreatinineDrug CombinationsInjections, SubcutaneousMaleRatsRats, Inbred StrainsSerotoninSexual Behavior, AnimalTime FactorsComparative StudyJournal Article

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G Gonzales, L Mendoza, J Ruiz, J Torrejón. 1982-12-13. A demonstration that 5-hydroxytryptamine administered peripherally can affect sexual behavior in male rats.. https://doi.org/10.1016/0024-3205(82)90724-x

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