PubMed HealthSearch

PubMed · 7159233

[Viral appendicitis].

Abstract

In order to study the appendix involvement with respiratory viruses in appendicitis, 44 cases of this disease in patients varying in ages from 14 to 71 years were investigated at random. Light microscopy and immunofluorescent examinations of the appendix were performed. The results were compared with those of serological blood tests done in the time course. In 20 patients the role of respiratory viruses and sometimes Mycoplasma pneumoniae proved to be doubtless by a significant rise in antibody titres (4-32-fold), as a rule, without any marked manifestations on the part of the respiratory organs. This was combined with detection of the antigen of the agent in enterocytes and with structural changes of the organ typical of these infections according to the results of previous examinations of the intestinal tract in generalized acute viral respiratory infections and mycoplasmosis. In 14 patients the role of respiratory viruses seemed to be likely. They showed positive results of immunofluorescent and light microscopy examinations without a significant rise in antibody titres, however. In 7 patients the role of respiratory viruses did not seem convincing: they had positive results of either immunofluorescence or serological tests alone. Three patients had no evidence of lesions caused by respiratory viruses or mycoplasma.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

A V Tsinzerling, G V Shastina, S P Vydumkina, T N Pisareva. 1982. [Viral appendicitis].. https://pubmed.ncbi.nlm.nih.gov/7159233/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Local succession of adenovirus strains in pediatric gastroenteritis.

Assessment of the current incidence of different adenovirus types in local gastroenteritis involved the examination of over 1,000 stool specimens annually from 1988-1992. Adenoviruses were detected by electron microscopy and/or cell culture in 32% of the specimens in which a viral pathogen was detected. The identification of every adenovirus isolate to type by neutralization with specific antisera against the first 6 types and by restriction analysis of nonneutralized isolates was started in 1990. Samples from 1988 and 1989 were examined retrospectively. Adenovirus strains were compared to those isolated in a study between 1980-1983. Enumeration of individual adenovirus types revealed a number of trends, demonstrating that rapid changes in the local incidence of several strains were occurring in Manitoba. The incidence of adenovirus type 40 (Ad40) as a cause of gastroenteritis was found to have fallen dramatically in recent years. The predominant cause of gastroenteritis in Manitoba is a variant strain of Ad41, increasing in predominance each year and now responsible for over a third of the symptomatic cases examined since 1990. The majority of restriction site differences of the Ad41 variant strain from the prototype strain Tak were mapped to the hexon and fiber genes, both of which code for the neutralizable external viral epitopes. The probability of the observed pattern of mutations occurring by chance was calculated as P < 0.0005, indicating a strong pressure for selection of these immunologically significant alterations to the viral proteins responsible for cell attachment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenovirus Infections, Human

The precipitating factor in coeliac disease.

In recent years, remarkable progress has been made in the elucidation of cereal protein structure and its relation to coeliac toxicity. Gluten proteins of wheat can be classified according to their primary structure into high-, medium- and low-molecular-weight (HMW, MMW, LMW) groups. Each of these groups contains two or three different protein types having partly homologous, partly unique, structural elements: chi- and gamma-type HMW subunits of glutenin (HMW group), omega 5 and omega 1,2-type gliadins (MMW group) and alpha-type gliadins, gamma-type gliadins and LMW subunits of glutenin (LMW group). Numerous proteins from the same type do exist with only a few modifications of the amino-acid sequence. The structure of the HMW and LMW group proteins can be divided into three and five domains, respectively. Most typical for each type and unique for cereals are the glutamine- and proline-rich domains containing repetitive sequences (HMW group: domain B; LMW group: domain I). omega-type gliadins consist almost entirely of repetitive sequences. Rye and barley, closely related to wheat, have protein types homologous to those of wheat. Early investigations showed that wheat gluten and, in particular, the alcohol-soluble gliadin fraction contained the factor toxic for coeliac patients. Equivalent protein fractions of rye, barley and probably oats were also considered to be toxic. The effects of toxic proteins were not destroyed by digestion with pepsin, trypsin and pancreatin. In-vivo (instillation) testing established the toxicity of alpha-type gliadins, and in-vitro (organ culture) testing of gliadin peptides demonstrated that the N-terminal region (domain I) of alpha-type gliadins is involved in activating coeliac disease. The longest sequences common for toxic peptides were found to be -Pro-Ser-Gln-Gln- and -Gln-Gln-Gln-Pro-. Various in-vitro tests and two in-vivo studies on synthetic peptides support the importance of one or both of these sequences. They do not occur in non-toxic food proteins and are characterized by their ability to form a beta-turn conformation. Although these sequences are probably not sufficient for toxicity in themselves, and other amino-acid residues are additionally required, they could serve as the starting point for further investigation.

Adenovirus Infections, Human