A new antithrombogenic material with long polyethyleneoxide chains.

Y Mori; S Nagaoka; H Takiuchi; T Kikuchi; N Noguchi; H Tanzawa; Y Noishiki

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PubMed · 7164281

A new antithrombogenic material with long polyethyleneoxide chains.

Y Mori·S Nagaoka·H Takiuchi·T Kikuchi·N Noguchi·H Tanzawa·Y Noishiki

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Abstract

The PVC-g-MnG polymers were synthesized by photo-induced graft copolymerization of methoxypoly (ethyleneoxide)monomethacrylate (MnG) with various chain lengths (n) of polyethyleneoxide (PEO) (n = 4, 9, 15, 23, 50, 100) as side chains to polyvinylchloride (PVC) with photo-sensitive dithiocarbamate groups. Antithrombogenicity has been evaluated in vitro and in vivo. The in vitro and in vivo results indicated that the adsorption of blood elements to the PVC-g-MnG significantly decreased with the increasing PEO chain length (n). From these findings it is suggested that the volume restriction effect resulted from the formation of long-chain PEO on the surface and which effectively suppresses the adsorption of blood elements and prevents the denaturation of blood elements.

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Adsorption Animals Biocompatible Materials Fibrinolytic Agents Microscopy, Electron, Scanning Polyethylene Glycols Polymethacrylic Acids Polyvinyl Chloride Rabbits Structure-Activity Relationship Journal Article

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Y Mori, S Nagaoka, H Takiuchi, T Kikuchi, N Noguchi, H Tanzawa, Y Noishiki. 1982. A new antithrombogenic material with long polyethyleneoxide chains.. https://pubmed.ncbi.nlm.nih.gov/7164281/

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