Changes in tumor oxygenation after localized microwave heating.

P Vaupel; J Otte; R Manz

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PubMed · 7167517

Changes in tumor oxygenation after localized microwave heating.

P Vaupel·J Otte·R Manz

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Abstract

Upon heating at 40 degrees C for 30 min, the oxygenation of the tumor tissue significantly improved compared with control conditions at 35 degrees C. In contradistinction to this, the tumor oxygenation significantly decreased directly after 43 degrees C hyperthermia. A further temperature rise to 45 degrees C caused the oxygenation to drop drastically because of a severe restriction of nutritive blood flow. The changes in tumor oxygenation during hyperthermia seem to be predominantly mediated through changes in tumor blood flow, which showed the same directional changes.

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Animals Blood Gas Analysis Blood Pressure Body Temperature Carcinoma, Ehrlich Tumor Erythrocytes Female Male Microwaves Oxygen Consumption Oxyhemoglobins Rats Rats, Inbred Strains Journal Article Research Support, Non-U.S. Gov't

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P Vaupel, J Otte, R Manz. 1982. Changes in tumor oxygenation after localized microwave heating.. https://pubmed.ncbi.nlm.nih.gov/7167517/

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