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PubMed · 7170063

Developmental changes in mouse brain polyamine metabolism.

S I Laitinen·P H Laitinen·O A Hietala·A E Pajunen·R S Piha
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Abstract

Mouse brain ornithine decarboxylase (ODC) activity is high at the time of birth, whereas S-adenosyl-L-methionine decarboxylase (SAM-DC) activity is low. ODC activity, and putrescine, spermidine and spermine concentrations decline rapidly during postnatal development to the low level characteristic of mature brains, while SAM-DC activity behaves in the opposite manner. The fluctuations in mouse brain polyamine metabolism are in accord with those found in the rat. The apparent Km values of ODC and SAM-DC for their substrates decline parallel with the decrease of substrate and product concentrations during ontogeny suggesting substrate and/or product dependent regulation of polyamine synthesis in the developing brain.

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Adenosylmethionine DecarboxylaseAgingAnimalsBrainCarboxy-LyasesKineticsMiceMice, Inbred StrainsOrnithine DecarboxylasePolyaminesPutrescineSpermidineSpermineJournal ArticleResearch Support, Non-U.S. Gov't

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S I Laitinen, P H Laitinen, O A Hietala, A E Pajunen, R S Piha. 1982. Developmental changes in mouse brain polyamine metabolism.. https://doi.org/10.1007/bf00965090

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