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A model implicating altered macrophage function in H-2 linked nonresponsiveness to hen lysozyme.

A Miller
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Abstract

Studies on the basis of differential responsiveness of H-2b mice to gallinaceous lysozymes suggest T cell involvement and active T cell suppression with those lysozymes not responded to. Results from other laboratories suggesting a directive role for macrophages through limited presentation are summarized. A model is presented proposing that suppressors (recognizing a determinant only on lysozymes not responded to) are present in all strains; that suppression requires antigen bridging between suppressor determinant and positive T determinant; that this bridge is disrupted in all strains but H-2b; and that this failure to disrupt the antigen bridge is a result of a genetically (Ia) controlled loss of a normal macrophage processing step.

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AnimalsAntibody FormationChickensGenetic LinkageH-2 AntigensImmunosuppression TherapyMacrophagesMajor Histocompatibility ComplexMiceMuramidaseJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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A Miller. 1978. A model implicating altered macrophage function in H-2 linked nonresponsiveness to hen lysozyme.. https://doi.org/10.1007/978-1-4615-8858-0_7

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