Immune transfer using spleen fragments.

R F Gagnon; I C MacLennan

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PubMed · 7175923

Immune transfer using spleen fragments.

R F Gagnon·I C MacLennan

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Abstract

The adequacy of spleen slices for the purpose of adoptive immune transfer was evaluated in rodents. Transfers using spleen cell suspensions and spleen slices were conducted in parallel from hyperimmune donors to non-immune intact and irradiated syngeneic recipients. It was demonstrated that the level of immune responsiveness attained with transfer of spleen slices was at least equal to and most often greater than that achieved with transfer of spleen cell suspensions.

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Animals Antibody Formation Antibody-Dependent Cell Cytotoxicity Immunization Immunization, Secondary Immunoglobulin G Immunoglobulin M Male Mice Mice, Inbred C3H Rats Spleen Transplantation, Isogeneic Comparative Study Journal Article Research Support, Non-U.S. Gov't

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R F Gagnon, I C MacLennan. 1982. Immune transfer using spleen fragments.. https://pubmed.ncbi.nlm.nih.gov/7175923/

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