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PubMed · 7177922

Metkephamid effects on operant behavior.

J D Leander·C R Wood
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Abstract

Intravenous injections of high doses of metkephamid (20 and 40 mg/kg) decreased responding by pigeons under a multiple fixed-ratio, fixed-interval schedule of grain presentation. Naloxone antagonized in a dose-related manner the suppression of behavior produced by 40 mg/kg of metkephamid. Daily maintenance on large doses (30 and 60 mg/kg PO) of dlmethadone produced a slight shift of the dose-effect curve of metkephamid to the right. The data suggest that the behavioral effects of metkephamid are due to an action at a mu-opioid receptor.

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AnimalsColumbidaeConditioning, OperantDose-Response Relationship, DrugEnkephalin, MethionineMaleTime FactorsJournal Article

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J D Leander, C R Wood. Metkephamid effects on operant behavior.. https://doi.org/10.1016/0196-9781(82)90013-4

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