Dopamine antagonists do not block testosterone-induced decrease in luteinizing hormone.

R E Chapin; G R Breese; R A Mueller

doi:10.1016/0091-3057(82)90345-8

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Dopamine antagonists do not block testosterone-induced decrease in luteinizing hormone.

R E Chapin·G R Breese·R A Mueller

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Abstract

These studies were designed to test the hypothesis that testosterone might lower circulating levels of luteinizing hormone (LH) in castrated male rats by activating dopaminergic neuronal systems. Blood samples were drawn from conscious rats through an indwelling cannula during the fourth and eight hours after subcutaneous administration of testosterone (1 or 5 mg/kg, in corn oil). Testosterone caused a dose-dependent decrease in plasma LH levels eight hours after administration. This decrease was not blocked by prior administration of the dopaminergic antagonists haloperidol and flupenthixol. This lack of effect of dopaminergic antagonists indicates that testosterone does not act primarily via dopaminergic activation to lower LH.

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Animals Castration Dopamine Antagonists Flupenthixol Haloperidol Luteinizing Hormone Male Rats Rats, Inbred Strains Testosterone Thioxanthenes Journal Article

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R E Chapin, G R Breese, R A Mueller. 1982. Dopamine antagonists do not block testosterone-induced decrease in luteinizing hormone.. https://doi.org/10.1016/0091-3057(82)90345-8

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