Experimental models for testing respiratory tract carcinogens.

U Mohr

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PubMed · 7182065

Experimental models for testing respiratory tract carcinogens.

U Mohr

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Abstract

The usefulness of the mouse, rat, and Syrian golden hamster as experimental models for studies of the development of respiratory tract cancer is considered. Three different application methods for examining the effects of environmental chemicals on the respiratory tract in these species are discussed: implantation, intratracheal instillation, and inhalation. The results of various investigations are presented to demonstrate that each particular method has both advantages and disadvantages. The techniques are also considered in comparison with the human situation and in the light of obtaining the most valid data for extrapolation to man. Brief attention is paid to the relevance to respiratory tract carcinogenesis of more recently developed organ and cell culture systems.

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Animals Carcinogens, Environmental Cricetinae Disease Models, Animal Drug Implants Mice Organ Culture Techniques Rats Respiratory Tract Neoplasms Journal Article

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U Mohr. 1982. Experimental models for testing respiratory tract carcinogens.. https://pubmed.ncbi.nlm.nih.gov/7182065/

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