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PubMed · 7182701

[Disorders of kidney function in hepatic coma].

H Lochs·G Kleinberger·W Druml
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Abstract

Renal function was evaluated in 80 patients with hepatic coma stage III-IV (24 patients had acute fulminant hepatic failure, 48 patients chronic hepatic failure, 8 patients had a mixed form). Urea, creatinine and electrolytes were measured in plasma and urine as well as creatinine clearance and sodium/potassium ratio in urine. Renal failure was defined as an increase of serum creatinine above 3 mg/dl. In 15 of the 24 patients with fulminant hepatic failure creatinine clearance was reduced; hyperaldosteronism was present in 13 cases; in 2 patients there was necrosis of the tubulus, in 9 patients overt renal failure. In patients with chronic hepatic failure creatinine clearance was pathological in 36 cases, hyperaldosteronism was diagnosed in 23 cases and necrosis of renal tubules in 3 cases; 8 patients had overt renal failure. In the group with the mixed form of hepatic coma creatinine clearance was pathological in 3 cases, in 6 cases hyperaldosteronism was diagnosed; necrosis of the tubules could not be found in this group; 4 patients had overt renal failure. It is suggested that for treatment of this condition dopamine should be given prophylactically as well as intravenous sodium and water substitution.

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Acute Kidney InjuryAdultCreatinineFemaleHepatic EncephalopathyHumansHyperaldosteronismKidney Function TestsKidney Tubular Necrosis, AcuteMaleMiddle AgedPotassiumSodiumUreaEnglish AbstractJournal Article

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H Lochs, G Kleinberger, W Druml. 1982. [Disorders of kidney function in hepatic coma].. https://pubmed.ncbi.nlm.nih.gov/7182701/

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