Cytoskeletal organization at the postsynaptic complex.

R L Gulley; T S Reese

doi:10.1083/jcb.91.1.298

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Cytoskeletal organization at the postsynaptic complex.

R L Gulley·T S Reese

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Abstract

Postsynaptic densities and the adjacent cytoskeleton were examined in deep-etched, unfixed slices of guinea pig anteroventral cochlear nucleus. The postsynaptic density seen in conventional thin sections corresponds to a meshwork of 4-nm filaments associated with intramembrane particles at the postsynaptic active zone of inhibitory as well as excitatory synapses. These filaments intermesh with a lattice of 8- to 9-nm microfilaments, tentatively identified as F-actin, that is concentrated under the postsynaptic density. We postulate that the meshwork of 4-nm filaments anchors receptors to the adjacent microfilament lattice; this extended postsynaptic complex may limit the mobility of receptors and help maintain the curvature of the postsynaptic membrane.

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R L Gulley, T S Reese. 1981. Cytoskeletal organization at the postsynaptic complex.. https://doi.org/10.1083/jcb.91.1.298

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