PubMed HealthSearch

PubMed · 7204090

[EEA stapler in colon surgery].

Abstract

The EEA stapler, for accomplishing stapled anastomoses in the gastrointestinal tract seems of a great interest. It opens new possibilities in case of carcinoma of the middle part of the rectum. It also makes the re-anastomose after a Hartmann procedure much easier. The results of 63 anastomoses on the colon or the rectum are reported.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J M Fiala, M C Marti, P Meyer, A Rohner. 1980. [EEA stapler in colon surgery].. https://pubmed.ncbi.nlm.nih.gov/7204090/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release.

The G12 subfamily of heterotrimeric G proteins, comprised of the alpha-subunits Galpha12 and Galpha13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis. In an attempt to elucidate specific roles of this subfamily in cell regulation, we sought to identify molecular targets of Galpha12. Here we show a specific interaction between the G12 subfamily and the cytoplasmic tails of several members of the cadherin family of cell-surface adhesion proteins. Galpha12 or Galpha13 binding causes dissociation of the transcriptional activator beta-catenin from cadherins. Furthermore, in cells lacking the adenomatous polyposis coli protein required for beta-catenin degradation, expression of mutationally activated Galpha12 or Galpha13 causes an increase in beta-catenin-mediated transcriptional activation. These findings provide a potential molecular mechanism for the previously reported cellular transforming ability of the G12 subfamily and reveal a link between heterotrimeric G proteins and cellular processes controlling growth and differentiation.

Adenocarcinoma