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Optimized mitochondrial function as a nutritional strategy in cancer immunotherapy.

M F McCarty
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Abstract

Activated macrophages require effective mitochondrial function, but mitochondrial efficiency is jeopardized by the free radicals produced naturally in macrophage metabolism. This perspective rationalizes the well-documented immunostimulant effects of coenzyme Q and of antioxidant nutrients such as selenium, vitamin E, and manganese. More generally, the nutritional optimization of mitochondrial function is proposed as a "neo-Warburgian' approach to cancer immunotherapy.

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AntioxidantsFree RadicalsImmunotherapyMacrophagesMitochondriaNeoplasmsOxidation-ReductionJournal Article

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M F McCarty. 1981. Optimized mitochondrial function as a nutritional strategy in cancer immunotherapy.. https://doi.org/10.1016/0306-9877(81)90021-9

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