Two distinct central serotonin receptors with different physiological functions.

S J Peroutka; R M Lebovitz; S H Snyder

doi:10.1126/science.7221567

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PubMed · 7221567

Two distinct central serotonin receptors with different physiological functions.

S J Peroutka·R M Lebovitz·S H Snyder

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Abstract

Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.

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Adenylyl Cyclases Animals Behavior, Animal Brain Guanine Nucleotides Kinetics Male Rats Receptors, Serotonin Serotonin Spiperone Structure-Activity Relationship Journal Article Research Support, U.S. Gov't, P.H.S.

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S J Peroutka, R M Lebovitz, S H Snyder. 1981-05-15. Two distinct central serotonin receptors with different physiological functions.. https://doi.org/10.1126/science.7221567

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