A new warfarin metabolite: structure and function.

M J Fasco; P P Dymerski; J D Wos; L S Kaminsky

doi:10.1021/jm00208a009

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A new warfarin metabolite: structure and function.

M J Fasco·P P Dymerski·J D Wos·L S Kaminsky

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Abstract

The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.

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Animals Blood Coagulation Chemical Phenomena Chemistry Cytochrome P-450 Enzyme System Enzyme Induction In Vitro Techniques Microsomes, Liver Mutagens Rats Salmonella Stereoisomerism Vitamin K 1 Warfarin Journal Article Research Support, U.S. Gov't, P.H.S.

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M J Fasco, P P Dymerski, J D Wos, L S Kaminsky. 1978. A new warfarin metabolite: structure and function.. https://doi.org/10.1021/jm00208a009

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