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PubMed · 7238433

Is glutamate a trigger factor in epileptic hyperactivity?

J Coutinho-Netto·A S Abdul-Ghani·J F Collins·H F Bradford
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Abstract

The effects of glutamate and aspartate antagonists were studied on limb-jerk frequency and EEG patterns in rats made epileptic by cobalt implantation in the sensorimotor cerebral cortex. The results of this study were as follows: (1) alpha-Amino-4-phosphonobutyric acid (0.055--1.10 mM) decreased or completely prevented the epileptic manifestations. The effect was reversible 30 min after washing with artificial CSF solution. (2) DL-Pyroglutamic acid completely abolished the myoclonic jerks and EEG spikes. (3) alpha-Amino-5-phosphonovaleric acid and alpha-D-amino-adipic acid significantly reduced the frequency of epileptic spikes and myoclonic jerks. (4) Other analogs, alpha-amino-3-phosphonopropionic acid (0.6 mM), alpha-amino phosphonocaproic acid (0.95), and hydroxy-3-amino pyrrolidone-2 were without effect. (5) Glutamate itself did not decrease the epileptic manifestations.

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Amino AcidsAminobutyratesAnimalsAspartic AcidCerebral CortexElectroencephalographyEpilepsyExcitatory Amino Acid AntagonistsFemaleGlutamatesOrganophosphorus CompoundsRatsSeizuresJournal ArticleResearch Support, Non-U.S. Gov't

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J Coutinho-Netto, A S Abdul-Ghani, J F Collins, H F Bradford. 1981. Is glutamate a trigger factor in epileptic hyperactivity?. https://doi.org/10.1111/j.1528-1157.1981.tb04112.x

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