Probenecid and intraocular methicillin.

S Grant

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PubMed · 7247178

Probenecid and intraocular methicillin.

S Grant

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Abstract

Probenecid was given intravenously to rabbits in an effort to extend the intraocular longevity of intravitreal methicillin. With relatively high levels of probenecid, an insignificant elevation of half-life was obtained. Aqueous levels of methicillin were measured after intravitreal injection and were found to be adequate to inhibit penicillinase-producing S. aureus for approximately 20 hours.

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Animals Aqueous Humor Drug Synergism Half-Life Methicillin Probenecid Rabbits Time Factors Vitreous Body Journal Article

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S Grant. 1981. Probenecid and intraocular methicillin.. https://pubmed.ncbi.nlm.nih.gov/7247178/

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