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PubMed · 7249401

Testosterone-antibiotic effectiveness on staphylococcus aureus infected rats.

M Atef·S M Sokkar
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Abstract

(1) Male castrated rats (testosterone-free) inoculated intraperitoneally with Staph. aureus showed severe damage in their internal organs as determined by pathological examination of the killed animals. (2) Penicillin-G, oxytetracycline and chloramphenicol treatment 24 h after injection markedly decreased the extent of damage. (3) Pretreatment of castrated rats with testosterone propionate for 3 successive days before infection had a protective influence on the internal organs. (4) Testosterone-injected rats when treated with different antibiotics, showed a clear synergistic action with penicillin-G and oxytetracycline but not chloramphenicol.

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AnimalsAnti-Bacterial AgentsChloramphenicolDrug SynergismMaleOxytetracyclinePenicillin GRatsStaphylococcal InfectionsStaphylococcus aureusTestosteroneJournal Article

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BibTeXRIS

M Atef, S M Sokkar. 1980. Testosterone-antibiotic effectiveness on staphylococcus aureus infected rats.. https://doi.org/10.1111/j.1440-1681.1980.tb00118.x

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