Brain acetylcholine synthesis declines with senescence.

G E Gibson; C Peterson; D J Jenden

doi:10.1126/science.7256270

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PubMed · 7256270

Brain acetylcholine synthesis declines with senescence.

G E Gibson·C Peterson·D J Jenden

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Abstract

The synthesis of whole brain acetylcholine is reduced in two strains (C57BL and BALB/c) of senescent mice. The incorporation of [U-14C]glucose into acetylcholine decreased in both strains by 40 +/- 4 per cent in 10-month-old mice and by 58 +/- 9 percent in 30-month-old mice compared with mice 3 months old. The incorporation of [2H4]choline into acetylcholine declined 60 and 73 percent in 10- and 30-month-old mice, respectively. Deficits in the cholinergic system may contribute to brain dysfunctions that complicate senescence.

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Acetylcholine Aging Animals Behavior, Animal Brain Choline Glucose Lactates Mice Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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G E Gibson, C Peterson, D J Jenden. 1981-08-07. Brain acetylcholine synthesis declines with senescence.. https://doi.org/10.1126/science.7256270

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