Schultz-Dale reaction in mouse trachea.

G A Koppel; K D Haisch; S M Spaethe; J R Schmidtke; J H Fleisch

doi:10.1016/0160-5402(81)90082-6

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PubMed · 7265992

Schultz-Dale reaction in mouse trachea.

G A Koppel·K D Haisch·S M Spaethe·J R Schmidtke·J H Fleisch

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Abstract

A method was developed to induce contraction of immunologically sensitized mouse trachea by antigen (Schultz-Dale reaction). The response was mediated by immunoglobulin (Ig) E antibody directed against either the hapten DNP, the hapten carrier conjugate DNP-keyhole limpet hemocyanin (KLH), or the unmodified carrier KLH. Tracheal contractions were elicited by DNP-KLH, KLH, or DNP-bovine serum albumin (BSA) but not by DNP or BSA alone. This procedure represents a useful index of in vitro anaphylaxis in mouse airway smooth muscle.

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Anaphylaxis Animals Antibodies Antigen-Antibody Reactions Antigens Dinitrophenols Female Hemocyanins In Vitro Techniques Mice Mice, Inbred BALB C Muscle Contraction Muscle, Smooth Trachea Journal Article

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G A Koppel, K D Haisch, S M Spaethe, J R Schmidtke, J H Fleisch. 1981. Schultz-Dale reaction in mouse trachea.. https://doi.org/10.1016/0160-5402(81)90082-6

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