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PubMed · 726892

Ampicillin penetration into the rabbit eye.

L Salminen
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Abstract

Distribution of intravenously injected ampicillin of 50 mg/kg was studied in the rabbit eye using radioactive tracer method. Antibiotic concentration regarded as therapeutic in the treatment of gram-negative organisms was obtained in all vascularized ocular structures. Intermediate values were measured from the cornea and aqueous humour. In the vitreous body and lens, ampicillin was unable to approach a concentration that would be effective against the common gram-negative organisms. The low ampicillin concentration in the vitreous body and lens was unchanged by systemically administered probenecid, which in other parts of the eye caused significantly higher ampicillin levels.

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AmpicillinAnimalsFemaleInjections, IntravenousMaleRabbitsJournal Article

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BibTeXRIS

L Salminen. 1978. Ampicillin penetration into the rabbit eye.. https://doi.org/10.1111/j.1755-3768.1978.tb03817.x

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